Related Papers
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
Adverse cutaneous drug reactions: Eight year assessment in hospitalized patients
2014 •
Zahra Nikyar
Adverse cutaneous drug reactions (ACDRs) are the most commonly reported adverse drug events. The causative drugs and clinical patterns of ACDRs are different in various populations. This study was conducted to identify the clinical patterns, causative drugs and reasons for drug administration in patients hospitalized due to ACDR. This retrospective study was carried out in a referral university hospital, Isfahan, Iran. The medical records of all patients who were hospitalized in the Dermatology Department due to ACDRs were reviewed covering an 8-year period between December 2006 and August 2013. A total number of 282 patients with the mean age of 29.48 ± 21.18 years were hospitalized in this time period, of which 61% were females. The most common clinical patterns regarding the final diagnosis were Stevens-Johnson syndrome (SJS) (32%), exanthematous drug eruptions (24.5%) and toxic epidermal necrolysis (TEN) (11%). Anticonvulsants were the most frequently implicated drug group (51.8...
IP innovative publication pvt. ltd
Evaluation of cutaneous adverse drug reactions in a tertiary care hospital
2019 •
IP Innovative Publication Pvt. Ltd.
Introduction: Skin is one of the most frequently involved organ in adverse drug reactions. A wide spectrum of reactions ranging from maculopapular rashes to toxic epidermal necrolysis can be caused by different classes of drugs. Objectives: To evaluate the cutaneous adverse drug reactions in a tertiary care hospital using standard assessment scales. Materials and methods: A retrospective study was conducted in the Dermatology department of a tertiary care hospital between June 2013 – May 2017. All the inpatient and outpatient records were analysed for Cutaneous adverse drug reactions (CADRs) during the study period. Results: Out of 124 patient case files reviewed, 90 patients were included in the study. Of these 90 patients, 55.6% were males. Maximum number of cases were in the age group of 20-39 years (37.8%). Fixed drug eruption and maculopapular rash were the most common CADRs reported. Type of drug reaction was not significantly associated with age and sex. The most common drugs implicated were antibiotics (33.3%) followed by NSAIDs (21.1%). Most of the patients were managed on outpatient basis (67.8%). Probable association was seen in 86.67% and 13.3% had a possible association. About 92.2% of CADRs were in the moderate category. Conclusion: Commonly used drugs can cause CADRs. Hence careful use of drugs weighing the benefit risk ratio is essential. Pharmacovigilance will play a vital role in monitoring ADRs especially those due to the newer drugs.
A Clinico-Etiological Study of Cutaneous Adverse Drug Reactions at Tertiary Care Centre
IOSR Journals
Background:Adverse drug reactions are important cause of morbidity ,hospitalization,increased health expenditure and even death.Adverse drugs are unavoidable consequences of drug therapy and can occur with any class of drugs.CADRs are the most frequent ADRs. Aim of this study is to recognise different clinical manifestations of CADRs and to find out the cause and identify the common offending drugs.Materials and Methods: A cross sectional study was done over a period of 9 months (from March 2019 to November 2019) after institutional ethics committee approval.All patients presenting to the dermatology OPD and IPD with cutaneous manifestations after drug consumptions and those referred from other departments are included in our study.Patients having incomplete history of drug intakewere excluded from the study.Results:A total of 136 CADRs are reported during the study period. Among 136 cases,74 were females and 62 males.Patients presented with Maculopapular rashes 53(38.97%),Drug induced urticaria 26(19.12%),FDE 21(15.44%),Acneiform eruptions 14(10.29%),Erythema multiforme 8(5.88%),Exfoliative dermatitis 7(5.15%),SJS-TEN 6(4.41%), DRESS 1(0.74%).Conclusion:Knowledge of pattern and offending drugs help in better management , reducing complications and preventing recurrences in these patients.
International Journal of Research in Dermatology
Prospective monitoring of cutaneous adverse drug reactions in a secondary care hospital, UAE
2019 •
Sathvik Sridhar
An observational study of drug induced cutaneous reactions used in various group of patients
2016 •
SEEMA DUA
Adverse drug reactions (ADRs) are noxious and unintended response to medicines. The detection and evaluation of ADRs of new drug is often delayed because they have long latency and are unexpected. But now a days pharmacovigilance surveillance system makes it possible for physicians, pharmacist and other health care providers to report suspected ADRs. The objective of this prospective study was to assess clinical pattern of drug induced cutaneous reactions in Dermatology OPD. In our study total of 60 patients with suspected cutaneous adverse drug reactions were recruited. A detailed physical examination was done by a physician including drug intake during 3 weeks preceding reactions and type of drug reactions. Most frequently reported cutaneous drug reactions were Stevens Johnson Syndrome (23%), Maculopapular rash (18%) Toxic Epidermal Necrolysis (15%) and were caused by antiepileptic drugs in 21(35%) patients, followed by antibiotics in 17(28.33%) cases, NSAID’s in 7(11.6%) cases, a...
Journal of Evolution of Medical and Dental Sciences
Pattern of Adverse Cutaneous Drug Reactions in a Tertiary Care Hospital
Anuradha Priyadarshini
Indian journal of dermatology, venereology and leprology
An epidemiological and clinical analysis of cutaneous adverse drug reactions seen in a tertiary hospital in Johor, Malaysia
siew choon, Nai Ming Lai
International journal of dermatology
Cutaneous adverse drug reactions seen in a tertiary hospital in Johor, Malaysia
2010 •
siew choon
Adverse drug reactions are most commonly cutaneous in nature. Patterns of cutaneous adverse drug reactions (ADRs) and their causative drugs vary among the different populations previously studied. Our aim is to determine the clinical pattern of drug eruptions and the common drugs implicated, particularly in severe cutaneous ADRs in our population. This study was done by analyzing the database established for all adverse cutaneous drug reactions seen from January 2001 until December 2008. A total of 281 cutaneous ADRs were seen in 280 patients. The most common reaction pattern was maculopapular eruption (111 cases, 39.5%) followed by Stevens-Johnson Syndrome (SJS: 79 cases, 28.1%), drug reaction with eosinophilia and systemic symptoms (DRESS: 19 cases, 6.8%), toxic epidermal necrolysis (TEN: 16 cases, 5.7 %), urticaria/angioedema (15 cases, 5.3%) and fixed drug eruptions (15 cases, 5.3%). Antibiotics (38.8%) and anticonvulsants (23.8%) accounted for 62.6% of the 281 cutaneous ADRs se...
Journal of Evidence Based Medicine and Healthcare
Clinico-Epidemiological Study of Cutaneous Adverse Drug Reactions: A Hospital-Based Study
Tanmay Padhi
Cutaneous adverse drug reactions: A one year prospective study
2017 •
Sandeep Kaushal
Background: Adverse cutaneous drug reactions are unwarranted effects of modern medicine. These unfortunate events can assume any morphology from simple exanthem to full blown toxic epidermal necrolysis (TEN), and can simulate and mimic many diseases. Sometimes it is difficult to recognize the cause, but they may be due to polypharmacy or self-administration of medications. The analytical data from this study might help us to see certain patterns with various drugs and shed light on this problem. We performed this study at a tertiary hospital in Punjab, Dayanand Medical College and Hospital (DMCH), in order to determine the clinical patterns of cutaneous manifestations of adverse drug reactions (ADR).Methods: The diagnosis was mainly based on detailed history and correlation between drug intake and the onset of rash along with laboratory investigations and skin biopsy results where possible. We assessed 695 patients (379 males and 316 females) who presented with cutaneous drug reacti...
